Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells
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Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells
Authors:
Xiaodong Ding
Changqing Ding
Fei Wang
Wenshuai Deng
Mingming Yu
Qinghai Meng
Peng Sun
View Affiliations
Affiliations: Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Neurosurgery, The Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China, Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China
Published online on: September 3, 2018
https://doi.org/10.3892/ol.2018.9377
Pages: 6095-6099
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Abstract
The present study aimed to observe the effect of the Notch1 signaling inhibitor γ‑secretase inhibitor II (GSI II) on the growth and differentiation of tumor cells. The tumor cell line U87 was grown in serum‑free media, and cell growth was evaluated using immunofluorescence. Single‑cell wall‑adherent growing conditions were prepared, GSI II was added, and the differentiation and growth of single tumor cells was evaluated. Immunofluorescence demonstrated positive results for the expression of Nestin and cluster of differentiation 133. The cell proliferation rate was reduced following the addition of GSI II (P